Objectives:

The purpose of this study was to determine whether spironolactone use is associated with fractures in men with congestive heart failure (CHF).

Background:

In rats with aldosteronism, spironolactone preserves skeletal strength. However, in humans, the relationship of spironolactone to fractures is not known.

Methods:

The medical records of all male patients with CHF from 1999 to 2005 treated at the Veterans Affairs Medical Center, Memphis, Tennessee, were ...

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